Yes, the Hodgdon rifle listing is insane.
Just wondering what Hodgdon rifle listing you are referring to as 'insane'?
If you are referencing the Load on the Hodgdon website the rifle data does NOT differ from the pistol data which is typical - and for your bullet/powder combo is 21 grains H110 for starting and 22 grains maximum.
Most (if not all) powder mfgs. DO NOT change any load data for rifles - they use the SAME data as in the pistol load category and simply post the results of that load in the manual as chronographed out of the rifle.
The only thing that will be different is the velocity due to the longer barrel but the powder charge is the same.
By comparison my 'old' Speer # 9 manual shows this same load as 19.5 grains starting and max at 21.5, and tested out of a Ruger Security Six. Definitely a 'Full House' load that should be approached carefully but not 'insane'.
I have shot 100's of similar loads using WW 296 (a H110 equivalent) with 19 grains and a 125 grain bullet out of both a Winchester Trapper and Henry .357 with no issues.
My question is why are you starting with essentially 'maximum' loads? It is far more prudent to start with lessor loads for plinking & range shooting. Unless you are hunting or have a need for maximum loads why load them? Much more pleasant (and less expensive) to shoot lower end loads.